胎盘
子痫前期
内分泌学
内科学
胆固醇侧链裂解酶
滋养层
胎儿
氯化镉
男科
生物
医学
怀孕
化学
镉
细胞色素P450
新陈代谢
遗传学
有机化学
作者
Xiaojie Zhang,Kai Chen,Meng Zhu,Ru Jia,Feifei Lian,Feng Lin
出处
期刊:Xenobiotica
[Informa]
日期:2022-06-03
卷期号:52 (6): 625-632
标识
DOI:10.1080/00498254.2022.2124204
摘要
Cadmium (Cd) is a toxic element, which is associated with preeclampsia (PE).We treated pregnant rats with cadmium chloride from gestational days (GDs) 9-12 to introduce the PE-like animal model. Maternal systolic blood pressures (SBPs) and body weights were measured on GDs 0, 5, 10, 15, and 20. Foetuses were delivered by Caesarean section on GD20. Then, the dams were sacrificed and the specimens were obtained. The morphological analysis of the placentae was carried out by haematoxylin and eosin staining examination and immunohistochemistry assay.Our study showed that Cd-treated rats developed PE-like phenotypes, such as hypertension, albuminuria, and foetal growth restriction. Moreover, Cd-injected rats displayed abnormal placental angiogenesis and lower progesterone (P4) levels. We further demonstrated that Cd also inhibited the mRNA and protein expressions of steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme (CYP11A1), and 3β-hydroxysteroid dehydrogenase 1 (3β-HSD1), which are involved in P4 synthesis in the rat placenta.Our study demonstrates that maternal Cd exposure disrupts the local synthesis of P4 in the placenta, which contributes to the onset of PE in pregnant rats. Supplementing P4 at the early gestational stage may be a promising therapeutic strategy to prevent PE, which requires further investigation.
科研通智能强力驱动
Strongly Powered by AbleSci AI