医学
内科学
脚踝
心脏病学
疾病
血管疾病
多元分析
外科
作者
Tatsuya Maruhashi,Masato Kajikawa,Shinji Kishimoto,Takayuki Yamaji,Takahiro Harada,Yu Hashimoto,Aya Mizobuchi,Shunsuke Tanigawa,Farina Mohamad Yusoff,Yukiko Nakano,Kazuaki Chayama,Ayumu Nakashima,Chikara Goto,Kenichi Yoshimura,Yukihito Higashi
标识
DOI:10.1016/j.atherosclerosis.2022.09.012
摘要
Abstract
Background and aims
Ankle-brachial index (ABI) has been used as a vascular marker of atherosclerosis for cardiovascular risk assessment. However, it is unclear whether there is a difference in cardiovascular risk between patients with low ABI (<1.00) in one leg (unilateral low ABI) and patients with low ABIs in both legs (bilateral low ABI). Therefore, we investigated the associations of cardiovascular disease (CVD) with unilateral low ABI and bilateral low ABI to determine whether cardiovascular risk is higher in patients with bilateral low ABI than in patients with unilateral low ABI. Methods
We measured ABI in 2226 subjects. Results
The prevalence of CVD was higher in patients with bilateral low ABI than in individuals with normal ABI (1.00–1.40) and patients with unilateral low ABI (49.2%, 25.7% and 17.0%, respectively; p < 0.001). Multivariate analysis revealed that bilateral low ABI was significantly associated with an increased risk of CVD (OR, 2.30; 95% CI, 1.16 to 4.54; p = 0.02), whereas there was no significant association between unilateral low ABI and CVD (OR, 0.83; 95% CI, 0.47 to 1.46; p = 0.51). Propensity score matching analysis showed that the prevalence of CVD was significantly higher in patients with bilateral low ABI than in patients with unilateral low ABI (45.5% vs. 27.3%, p = 0.02). Conclusions
Cardiovascular risk may be higher in patients with bilateral low ABI than in patients with unilateral low ABI. More attention should be paid to whether a low ABI is present in one leg or in both legs for more precise cardiovascular risk assessment.
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