机械生物学
转移
癌细胞
信号转导
肿瘤微环境
癌症研究
生物
机械转化
癌症
转导(生物物理学)
神经科学
细胞生物学
肿瘤细胞
遗传学
生物物理学
作者
Antonios N. Gargalionis,Kostas A. Papavassiliou,Athanasios G. Papavassiliou
标识
DOI:10.1016/j.bbadis.2022.166555
摘要
Mechanical features of cancer cells emerge as a distinct trait during development and progression of solid tumors. Herein, we discuss recent key findings regarding the impact of various types of mechanical stresses on cancer cell properties. Data suggest that different mechanical forces, alterations of matrix rigidity and tumor microenvironment facilitate cancer hallmarks, especially invasion and metastasis. Moreover, a subset of mechanosensory proteins are responsible for mediating mechanically induced oncogenic signaling and response to chemotherapy. Delineating cancer dynamics and decoding of respective signal transduction mechanisms will provide new therapeutic strategies against solid tumors in the future.
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