Protein UHRF1-mediated dual dysregulation of molecular chaperone GRP78 induces endoplasmic reticulum stress and aggravates diabetic nephropathy

Overall, our findings establish the dual epigenetic regulatory mechanisms of GRP78 and demonstrate its role as a transcriptional regulator of ER stress-related gene expression, which drives tubular cells injury in DN. This suggests that targeting the nuclear translocation of GRP78 may serve as a novel therapeutic approach for DN.