恩替卡韦
医学
肝细胞癌
肝切除术
乙型肝炎病毒
内科学
胃肠病学
比例危险模型
乙型肝炎
倾向得分匹配
癌
替诺福韦
肝癌
肿瘤科
外科
病毒
人类免疫缺陷病毒(HIV)
免疫学
拉米夫定
切除术
作者
Wei Yu Kao,Elise Chia‐Hui Tan,Hsin‐Lun Lee,Yi Hsiang Huang,Teh Ia Huo,Chun Chao Chang,Jeng‐Fong Chiou,Ming‐Chih Hou,Jaw‐Ching Wu,Chien–Wei Su
摘要
There is still controversy about whether tenofovir disoproxil fumarate (TDF) and entecavir (ETV) have different effects on the outcomes of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).The aim of this study was to compare the prognoses between ETV and TDF treatment among patients with HBV-related HCC after hepatectomy.An analysis was done on data from the Taiwan Cancer Registry, which was linked to Taiwan National Health Insurance Research Database, for the years 2011-2016. We identified 7107 patients with HBV-related HCC after curative hepatectomy, and 25.3% of them used ETV or TDF after surgery. After propensity score overlap weighting, 1797 patients treated with ETV (n = 1365) or TDF (n = 432) were included for analyses. Cox proportional hazards models were used to compare the efficacy of ETV and TDF for recurrence and overall survival (OS).After hepatectomy, the recurrence rate per 100 person-years was 14.87 for the ETV group and 9.25 for the TDF group. The risk of recurrence was similar in the TDF group and the ETV group (HR [95% CI]: 0.91 [0.69-1.19; p = 0.479]), as was the risk of all-cause mortality (HR [95% CI]: 0.67 [0.42-1.07]; p = 0.091). When considering early recurrence (<2 years) and late recurrence (≧2 years), the TDF and ETV groups showed no significant differences. Subgroup analyses and sensitivity analyses demonstrated consistent results.Both TDF and ETV showed similar health benefits in terms of recurrence and OS in patients with HBV-related HCC patients after hepatectomy.
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