Endogenous Glucagon‐Like Peptide‐1 Receptor and Glucose‐Dependent Insulinotropic Polypeptide Receptor Signaling Inhibits Aeroallergen‐Induced Innate Airway Inflammation

Anti-inflammatory effects of incretin signaling through the glucagon-like peptide-1 receptor (GLP-1R) and the glucose-dependent insulinotropic polypeptide receptor (GIPR) in mice have been reported. Therefore, we hypothesized that signaling through the endogenous GLP-1R and the GIPR individually decreases allergic airway inflammation and that the combination of GLP-1R and GIPR signaling together additively inhibits allergen-induced lung and airway inflammation.