聚丙烯腈
癌胚抗原
材料科学
表面等离子共振
纳米纤维
检出限
光纤布拉格光栅
光纤
涂层
光纤传感器
纤维
纳米技术
光电子学
光学
纳米颗粒
化学
聚合物
色谱法
医学
癌症
物理
波长
内科学
复合材料
作者
Jinze Li,Xin Liu,Hao Sun,Jiawei Xi,Chang Chen,Li Deng,Yanxin Yang,Xiang Li
出处
期刊:Optics Express
[Optica Publishing Group]
日期:2024-05-07
卷期号:32 (11): 20024-20024
被引量:2
摘要
An optical fiber sensing probe using a composite sensitive film of polyacrylonitrile (PAN) nanofiber membrane and gold nanomembrane is presented for the detection of a carcinoembryonic antigen (CEA), a biomarker associated with colorectal cancer and other diseases. The probe is based on a tilted fiber Bragg grating (TFBG) with a surface plasmon resonance (SPR) gold nanomembrane and a functionalized polyacrylonitrile (PAN) PAN nanofiber coating that selectively binds to CEA molecules. The performance of the probe is evaluated by measuring the spectral shift of the TFBG resonances as a function of CEA concentration in buffer. The probe exhibits a sensitivity of 0.46 dB/(µg/ml), a low limit of detection of 505.4 ng/mL in buffer, and a good selectivity and reproducibility. The proposed probe offers a simple, cost-effective, and a novel method for CEA detection that can be potentially applied for clinical diagnosis and monitoring of CEA-related diseases.
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