Epigenetics‐Driven Appetite System Disorders and PI3K/AKT Signaling Activation Mediate a Weight Gain Resistance Phenotype Induced by a High‐Fat Diet in Male Rats

Our study suggests that 5mC-mediated molecular disturbances in the hypothalamic appetite system and activation of PI3K/Akt signaling in the VMH may serve as a potential pathogenic basis for HFWR.