Association of Social Isolation From Living Alone and Psychological Distress Among Adults With Chronic Liver Disease in the United States

INTRODUCTION: Little is known about the effect of social isolation on psychological outcomes among adults with chronic liver disease (CLD). METHODS: Using the US National Health Interview Survey (2014–2018), we explored the associations between social isolation from living alone and serious psychological distress and the moderating effect of neighborhood social cohesion (NSC) among adults with CLD. RESULTS: Adults with CLD who lived alone had 1.8 times higher adjusted odds of reporting serious psychological distress. High NSC moderated these findings. DISCUSSION: Social isolation is a social risk factor among US adults with CLD that may be moderated by NSC.