Association of Social Isolation from Living Alone and Psychological Distress Among Adults with Chronic Liver Disease in the United States

Objectives: Little is known about the effect of social isolation on psychological outcomes of adults with chronic liver disease (CLD). Methods: Using the US National Health Interview Survey (2014-2018), we explored the associations between social isolation from living alone and serious psychological distress and the moderating effect of neighborhood social cohesion (NSC) among adults with CLD. Results: Adults with CLD who lived alone had 1.8 times higher adjusted odds of reporting serious psychological distress. High NSC moderated these findings. Conclusions: Social isolation is a social risk factor among US adults with CLD that may be moderated by NSC.