Emotion Generation and Regulation in Premenstrual Dysphoric Disorder: Dysregulation of Large-Scale Brain Networks Across the Menstrual Cycle

Multiple network aberrations during the luteal phase may explain the development of mood symptoms during the luteal phase. Furthermore, higher baseline (follicular) SN activity may render women with PMDD more susceptible to severe mood symptoms in response to hormonal fluctuations. What drives increased SN activity in the follicular phase is unknown, but innate and neuroplastic mechanisms have been proposed.