Selective oxidation of Cu‐UiO‐66‐NH2 methane by piezoelectric catalysis under mild conditions

Selective partial oxidation of methane (CH₄) at room temperature is a challenge in catalytic chemistry. Herein, we report a piezoelectric‐responsive metal‐organic framework (MOF), Cu‐UiO‐66‐NH₂, as an efficient catalyst to convert CH4 to C1 products selectively. In flow reactors under ultrasonic activation, this catalyst achieves a methanol production rate of 175.1 μmol·g⁻¹·h⁻¹ with 82% selectivity. Parallel experiments in batch reactors demonstrate yields of CO (297.4 μmol·g⁻¹·h⁻¹) and H₂ (140.6 μmol·g⁻¹·h⁻¹). In the piezocatalytic process, in situ generated H2O2 was decomposed to produce hydroxyl radical (·OH) to active C‐H of CH4. Cu(II)‐O· species could formed from the decomposition of Cu(Ⅱ)‐OOH intermediate to selective partial oxidation CH4 but not to form CO2. This MOF‐based catalyst design integrated piezocatalysis and mimics enzymatic catalysis, supplying new insight to develop robust catalysts for the industrial conversion of methane with low concentration (＜10%).