Harnessing the power of iridium AIEgens for NAD(P)H detection in aqueous medium and living cells

A rationally designed luminescent probe based on cyclometalated iridium(III) AIEgens was developed for the rapid, sensitive, and specific detection of NAD(P)H in aqueous media. This probe was successfully utilized for bioimaging of NADH within the mitochondria of living cancer cells, highlighting its potential as a valuable tool for investigating NADH-associated cellular processes.