微乳液
动态光散射
化学
金属有机骨架
压片
胶体
吸附
剂型
固体脂质纳米粒
色谱法
药物输送
有机化学
纳米颗粒
材料科学
纳米技术
肺表面活性物质
生物化学
作者
Lena Scheller,Stephanie Bachmann,Theresa Zorn,Simon Hanio,Uwe Gbureck,Dimitrios G. Fatouros,Ann‐Christin Pöppler,Lorenz Meinel
标识
DOI:10.1016/j.ejpb.2023.03.010
摘要
Poorly water-soluble drugs are frequently formulated with lipid-based formulations including microemulsions and their preconcentrates. We detailed the solidification of drug-loaded microemulsion preconcentrates with the acid-sensitive metal-organic framework ZIF-8 by X-ray powder diffraction and solid-state nuclear magnetic resonance spectroscopy. Adsorption and desorption dynamics were analyzed by fluorescence measurement, high-performance liquid chromatography, dynamic light scattering and 1H-DOSY experiments using the model compounds Nile Red, Vitamin K1, and Lumefantrine. Preconcentrates and drugs were successfully loaded onto ZIF-8 while preserving its crystal structure. The solid powder was pressable to tablets or 3D-printed into oral dosage forms. At low pH, colloidal solutions readily formed, solubilizing the poorly water-soluble compounds. The use of stimuli-responsive metal organic frameworks as carriers for the oral delivery of lipid-based formulations points towards solid dosage forms readily forming colloidal microemulsions.
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