自噬
脂锚定蛋白
TFEB
溶酶体
细胞生物学
生物发生
ESCRT公司
内体
生物
泛素
化学
生物化学
细胞内
基因
细胞凋亡
酶
作者
Dale Corkery,Andrei Ursu,Belén Lucas,Michael Grigalunas,Simon Kriegler,Rosario Oliva,Robert Dec,Sandra Koska,Axel Pahl,Sonja Sievers,Slava Ziegler,Roland Winter,Yao‐Wen Wu,Herbert Waldmann
标识
DOI:10.1002/cbic.202300579
摘要
Lipidation of the LC3 protein has frequently been employed as a marker of autophagy. However, LC3-lipidation is also triggered by stimuli not related to canonical autophagy. Therefore, characterization of the driving parameters for LC3 lipidation is crucial to understanding the biological roles of LC3. We identified a pseudo-natural product, termed Inducin, that increases LC3 lipidation independently of canonical autophagy, impairs lysosomal function and rapidly recruits Galectin 3 to lysosomes. Inducin treatment promotes Endosomal Sorting Complex Required for Transport (ESCRT)-dependent membrane repair and transcription factor EB (TFEB)-dependent lysosome biogenesis ultimately leading to cell death.
科研通智能强力驱动
Strongly Powered by AbleSci AI