三萜类
一氧化氮
消炎药
IC50型
化学
阳性对照
传统医学
萜烯
立体化学
生物
体外
生物化学
药理学
医学
有机化学
作者
Yang Xing,Shi-Li Wu,Baojing Li,Yanping Li,Hongping He,Dong Fan
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-12-01
卷期号:171: 105709-105709
标识
DOI:10.1016/j.fitote.2023.105709
摘要
Nineteen triterpenoids, including five previously unknown (four triucallane-type derivatives and one highly oxidized A, B-seco limonoids), together with fourteen known triterpenoids, were isolated from the fruits of Aphanamixis polystachya. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated their anti-inflammatory activities. The result showed that all compounds inhibit LPS-induced nitric oxide production in RAW264.7 macrophages with their IC50 value ranging from 95 to 1332 uM, and compound 6 exhibited obvious anti-inflammatory activity comparable to that of the positive control, with IC50 values of 94.96 uM.
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