表皮(动物学)
细胞角蛋白
细胞生物学
角蛋白
角质形成细胞
细胞骨架
生物
人体皮肤
体内
皮肤修复
伤口愈合
下调和上调
微管
肌动蛋白
中间灯丝
病理
细胞
体外
解剖
免疫学
免疫组织化学
医学
生物化学
生物技术
古生物学
基因
遗传学
作者
Katarzyna Michalak-Mićka,Celina Tenini,Sophie Böttcher‐Haberzeth,Luca Mazzone,Luca Pontiggia,Agnes S. Klar,Ueli Moehrlen,Thomas Biedermann
标识
DOI:10.1002/biot.202300246
摘要
Keratinocytes are the predominant cell type of skin epidermis. Through the programmed process of differentiation, they form a cornified envelope that provides a physical protective barrier against harmful external environment. Keratins are major structural proteins of keratinocytes that together with actin filaments and microtubules form the cytoskeleton of these cells. In this study, we examined the expression pattern and distribution of cytokeratin 6a (CK6a) in healthy human skin samples of different body locations, in fetal and scar skin samples, as well as in dermo-epidermal skin substitutes (DESSs). We observed that CK6a expression is significantly upregulated in fetal skin and scar tissue as well as in skin grafts after short-term transplantation. Importantly, the abundance of CK6a corresponds directly to the expression pattern of wound healing marker CK16. We postulate that CK6a is a useful marker to accurately evaluate the homeostatic state of DESSs.
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