睡眠剥夺
睡眠(系统调用)
内科学
内分泌学
年轻人
海马体
新陈代谢
酮体
贫困
医学
生理学
生物
昼夜节律
计算机科学
操作系统
作者
Arjun Sengupta,Jennifer C Tudor,Danielle Cusmano,Joseph A. Baur,Ted Abel,Aalim M. Weljie
出处
期刊:Sleep
[Oxford University Press]
日期:2023-09-20
卷期号:46 (11)
被引量:1
标识
DOI:10.1093/sleep/zsad246
摘要
Insufficient sleep is a concerning hallmark of modern society because sleep deprivation (SD) is a risk factor for neurodegenerative and cardiometabolic disorders. SD imparts an aging-like effect on learning and memory, although little is known about possible common molecular underpinnings of SD and aging. Here, we examine this question by profiling metabolic features across different tissues after acute SD in young adult and aged mice.Young adult and aged mice were subjected to acute SD for 5 hours. Blood plasma, hippocampus, and liver samples were subjected to UPLC-MS/MS-based metabolic profiling.SD preferentially impacts peripheral plasma and liver profiles (e.g. ketone body metabolism) whereas the hippocampus is more impacted by aging. We further demonstrate that aged animals exhibit SD-like metabolic features at baseline. Hepatic alterations include parallel changes in nicotinamide metabolism between aging and SD in young animals. Overall, metabolism in young adult animals is more impacted by SD, which in turn induces aging-like features. A set of nine metabolites was classified (79% correct) based on age and sleep status across all four groups.Our metabolic observations demonstrate striking parallels to previous observations in studies of learning and memory and define a molecular metabolic signature of sleep loss and aging.
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