促炎细胞因子
自愈水凝胶
伤口愈合
体内
炎症
金属有机骨架
材料科学
背景(考古学)
化学
吸附
药理学
细胞生物学
免疫学
医学
有机化学
生物
古生物学
生物技术
作者
UnJin Ryu,Pham Ngoc Chien,Suin Jang,Tung X. Trinh,Hyeon Shin Lee,Le Thi Van Anh,Xin Rui Zhang,Nguyen Ngan Giang,Nguyễn Văn Long,Sun‐Young Nam,Chan Yeong Heo,Kyung Min Choi
标识
DOI:10.1002/adhm.202301679
摘要
The regulation of proinflammatory mediators has been explored to promote natural healing without abnormal inflammation or autoimmune response induced by their overproduction. However, most efforts to control these mediators have relied on pharmacological substances that are directly engaged in biological cycles. It is believed that functional porous materials removing target mediators provide a new way to promote the healing process using their adsorption mechanisms. In this study, the Zr-based metal-organic frameworks (MOF)-808 (Zr6 O4 (OH)4 (BTC)2 (HCOO)6 ) crystals are found to be effective at removing proinflammatory mediators, such as nitric oxide (NO), cytokines, and reactive oxygen species (ROS) in vitro and in vivo, because of their porous structure and surface affinity. The MOF-808 crystals are applied to an in vivo skin wound model as a hydrogel dispersion. Hydrogel containing 0.2 wt% MOF-808 crystals shows significant improvement in terms of wound healing efficacy and quality over the corresponding control. It is also proven that the mode of action is to remove the proinflammatory mediators in vivo. Moreover, the application of MOF-808-containing hydrogels promotes cell activation, proliferation and inhibits chronic inflammation, leading to increased wound healing quality. These findings suggest that Zr-based MOFs may be a promising drug-free solution for skin problems related to proinflammatory mediators.
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