足细胞
兰尼定受体
细胞生物学
TRPC公司
钙信号传导
信号转导
口腔1
TRPC6型
电压依赖性钙通道
内质网
钙敏感受体
VDAC1型
刺激1
化学
受体
钙
瞬时受体电位通道
生物
内科学
内分泌学
钙代谢
肾
医学
生物化学
蛋白尿
大肠杆菌
细菌外膜
基因
作者
Yu-Chi Tu,Hua-Pan Shu,Lulu Sun,Qian-Qian Liao,Feng Liang,Man Ren,Lei Yao
标识
DOI:10.31083/j.fbl2810240
摘要
Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ concentration, and Ca2+ flow into podocytes, after activation of Ca2+ channels (such as transient receptor potential canonical (TRPC) channels and N-type calcium channels) by different stimuli. In addition, the type 2 ryanodine receptor (RyR2) and the voltage-dependent anion channel 1 (VDAC1) on mitochondrial store-operated calcium channels (SOCs) on the endoplasmic reticulum maintain the Ca2+ homeostasis of the organelle. Ca2+ signaling is transmitted through multiple downstream signaling pathways and participates in the morphogenesis, structural maintenance, and survival of podocytes. When Ca2+ is dysregulated, it leads to the occurrence and progression of various diseases, such as focal segmental glomerulosclerosis, diabetic kidney disease, lupus nephritis, transplant glomerulopathy, and hypertensive renal injury. Ca2+ signaling is a promising therapeutic target for podocyte-related diseases. This review first summarizes the role of Ca2+ sensing, Ca2+ channels, and different Ca2+-signaling pathways in the biological functions of podocytes, then, explores the status of Ca2+ signaling in different podocyte-related diseases and its advances as a therapeutic target.
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