表皮(毛发)
蟑螂
节肢动物角质层
生物
氯氰菊酯
拟除虫菊酯
渗透(战争)
蜚蠊目
毒理
植物
昆虫
杀虫剂
生态学
解剖
运筹学
工程类
作者
Tong Cai,Xuejun Wang,Baorui Liu,Hongyu Zhao,C. Liu,Xiancui Zhang,Yuting Zhang,Hui-Yuan Gao,Coby Schal,Fan Zhang
标识
DOI:10.1016/j.ijbiomac.2023.127642
摘要
Overuse of insecticides has led to severe environmental problems. Insect cuticle, which consists mainly of chitin, proteins and a thin outer lipid layer, serves multiple functions. Its prominent role is as a physical barrier that impedes the penetration of xenobiotics, including insecticides. Blattella germanica (L.) is a major worldwide indoor pest that causes allergic disease and asthma. Extensive use of pyrethroid insecticides, including β-cypermethrin, has selected for the rapid and independent evolution of resistance in cockroach populations on a global scale. We demonstrated that BgCPLCP1, the first CPLCP (cuticular proteins of low complexity with a highly repetitive proline-rich region) family cuticular protein in order Blattodea, contributes to insecticide penetration resistance. Silencing BgCPLCP1 resulted in 85.0 %-85.7 % and 81.0 %-82.0 % thinner cuticle (and especially thinner endocuticle) in the insecticide-susceptible (S) and β-cypermethrin-resistant (R) strains, respectively. The thinner and more permeable cuticles resulted in 14.4 % and 20.0 % lower survival of β-cypermethrin-treated S- and R-strain cockroaches, respectively. This study advances our understanding of cuticular penetration resistance in insects and opens opportunities for the development of new efficiently and environmentally friendly insecticides targeting the CPLCP family of cuticular proteins.
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