CLINICAL RECOGNITION AND TREATMENT OF ACUTE POTASSIUM INTOXICATION

医学 内科学 排泄 内分泌学 化学 有机化学
出处
期刊:Annals of Internal Medicine [American College of Physicians]
卷期号:33 (4): 797-797 被引量:115
标识
DOI:10.7326/0003-4819-33-4-797
摘要

Article1 October 1950CLINICAL RECOGNITION AND TREATMENT OF ACUTE POTASSIUM INTOXICATIONJOHN P. MERRILL, M.D., HAROLD D. LEVINE, M.D., F.A.C.P., WALTER SOMERVILLE, M.D., M.R.C.P., STEPHEN SMITH 3rd, M.D.JOHN P. MERRILL, M.D.Search for more papers by this author, HAROLD D. LEVINE, M.D., F.A.C.P.Search for more papers by this author, WALTER SOMERVILLE, M.D., M.R.C.P.Search for more papers by this author, STEPHEN SMITH 3rd, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-4-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe toxicity to the living organism of an excess of potassium ion in the extracellular fluid has been recognized for many years.1, 2, 3 The accumulation of toxic amounts of potassium may occur by reason of: (1) excess intake,2, 4, 5 (2) faulty metabolic handling,6 and (3) decreased excretion of potassium liberated by catabolic processes.7, 8, 9 The syndrome is encountered most frequently in clinical practice as a consequence of impaired excretion of potassium in the presence of increased mobilization or intake.The clinical syndrome of potassium intoxication has been recognized with increasing frequency10, 11, 12, 13, 14and the...Bibliography1. Ringer S: A further contribution regarding the influence of the deficient constituents of the blood on the contraction of the heart, J. Physiol. 4: 29-42, 1883. CrossrefMedlineGoogle Scholar2. Smillie WG: Potassium poisoning in nephritis, Arch. Int. Med. 16: 330, 1915. CrossrefGoogle Scholar3. Martin EG: The inhibitory influence of potassium chloride on the (terrapin) heart and the effect of variations of temperature upon this inhibition and upon vagus stimulation, Am. J. Physiol. 11: 370, 1904. CrossrefGoogle Scholar4. WinklerHoffSmith AWHEPK: Toxicity of orally administered potassium salts in renal insufficiency, J. Clin. Investigation 20: 119, 1941. CrossrefMedlineGoogle Scholar5. KeithKingOsterberg NMHEAE: Serum concentration and renal clearance of potassium in severe renal insufficiency in man, Arch. Int. Med. 71: 675, 1943. CrossrefGoogle Scholar6. HoffmanJacobs WSHR: The partition of potassium between the serum and corpuscles in health and disease, J. Lab. and Clin. Med. 19: 633, 1934. Google Scholar7. WinklerHoffSmith AWHEPK: Electrocardiographic changes and concentration of potassium in serum following intravenous injection of potassium chloride, Am. J. Physiol. 124: 478, 1938. CrossrefGoogle Scholar8. HoffSmithWinkler HEPKAW: The cause of death in experimental anuria, J. Clin. Investigation 20: 607, 1941. CrossrefMedlineGoogle Scholar9. ElkintonTarailPeters JRRJP: Transfers of potassium in renal insufficiency, J. Clin. Investigation 28: 378-388, 1949. CrossrefMedlineGoogle Scholar10. FinchMarchand CAJF: Cardiac arrest by action of potassium, Am. J. M. Sc. 206: 507, 1943. CrossrefGoogle Scholar11. MarchandFinch JFCA: Fatal spontaneous potassium intoxication in patients with uremia, Arch. Int. Med. 73: 384, 1944. CrossrefGoogle Scholar12. FinchSawyerFlynn CACGJJ: Clinical syndrome of potassium intoxication, Am. J. Med. 1: 337, 1946. CrossrefMedlineGoogle Scholar13. Bywaters EG: Ischemic muscle necrosis, J. A. M. A. 124: 1103, 1944. CrossrefGoogle Scholar14. NicholsonSpaeth WMW: Some clinical manifestations of abnormal potassium metabolism, South. M. J. 42: 77, 1949. CrossrefMedlineGoogle Scholar15. KeithBurchellBaggenstoss NMHBAH: Electrocardiographic changes in uremia associated with a high concentration of serum potassium, Am. Heart J. 27: 817, 1944. CrossrefGoogle Scholar16. StewartShepardHorger HJEMEL: Electrocardiographic manifestations of potassium intoxication, Am. J. Med. 6: 821, 1948. CrossrefGoogle Scholar17. Tarail R: Relation of abnormalities in concentration of serum potassium to electrocardiographic disturbances, Am. J. Med. 6: 828, 1948. CrossrefGoogle Scholar18. Zoethout WD: On the influence of sodium chloride and Ca chloride in the potassium contraction, Am. J. Physiol. 23: 374, 1908. CrossrefGoogle Scholar19. AmbergHelmholz SHF: The detoxifying action of sodium salt on potassium salt in the guinea pig, J. Pharmacol. and Exper. Therap. 12: 19, 1919. Google Scholar20. WinklerHoffSmith AWHEPK: Factors affecting the toxicity of potassium, Am. J. Physiol. 127: 430, 1939. CrossrefGoogle Scholar21. HarropBenedict GAEM: The role of phosphate and potassium in carbohydrate metabolism following insulin administration, Proc. Soc. Exper. Biol. and Med. 20: 430, 1922. CrossrefGoogle Scholar22. Holler JW: Potassium deficiency occurring during the treatment of diabetic acidosis, J. A. M. A. 131: 1188, 1946. Google Scholar23. NicholsonBranning WMWS: Potassium deficiency in diabetic acidosis, J. A. M. A. 134: 1292, 1947. CrossrefMedlineGoogle Scholar24. NadlerBelletLanning CSSM: Influence of the serum potassium and other electrolytes on the electrocardiogram in diabetic acidosis, Am. J. Med. 6: 838, 1948. CrossrefGoogle Scholar25. Darrow DC: Body fluid physiology. The relation of tissue composition to problems of water and electrolyte balance, New England J. Med. 233: 91, 1945. CrossrefGoogle Scholar26. ReinekeHollandStutzman RMCFL: Homeostasis of potassium in the extracellular fluid of the dog during removal by vivodialysis, Am. J. Physiol. 156: 290, 1949. CrossrefMedlineGoogle Scholar27. StutzmanReineke FLRM: Reduction of plasma potassium concentration of the dog by vivodialysis and its restoration in non-visceral regions, Am. J. Physiol. 157: 401, 1949. CrossrefMedlineGoogle Scholar28. Stock RJ: Acute urinary suppression, Am. J. Med. 7: 45, 1949. CrossrefMedlineGoogle Scholar29. WenerStansfieldHoffWinter JHHENA: Potassium intoxication from hemolysis of red cells, Am. Heart J. 37: 881, 1949. CrossrefMedlineGoogle Scholar30. BarkerShroderRanyoni PSELE: The effects of alkalosis and acidosis upon the human EKG, Am. Heart J. 17: 169, 1939. CrossrefGoogle Scholar31. MartinWertman HEM: Electrolyte changes and the electrocardiogram in diabetic acidosis, Am. Heart J. 34: 646, 1947. CrossrefMedlineGoogle Scholar32. ElkintonWinklerDanowski JRAWTS: Transfers of cell sodium and potassium in experimental and clinical conditions, J. Clin. Investigation 27: 74, 1948. CrossrefMedlineGoogle Scholar33. WenerdeLeev JNK: Role of potassium in dialyzing fluid in treatment with the artificial kidney, Proc. Soc. Exper. Biol. and Med. 71: 18, 1942. CrossrefGoogle Scholar34. Fenn WO: The deposition of potassium, phosphate and glycogen in rat livers, J. Biol. Chem. 128:297, 1939. CrossrefGoogle Scholar35. Hoff HE: Medical progress. Physiology, New England J. Med. 231: 526, 1944. CrossrefGoogle Scholar36. CrismanCrismanCalabreseDarrow JMCSMDC: Electrolyte redistribution in cat heart and skeletal muscle in potassium poisoning, Am. J. Physiol. 139: 667, 1943. CrossrefGoogle Scholar37. McLeanBayHastings FCEBAB: Electrical changes in the isolated heart of the rabbit following changes in the potassium content of the perfusing fluid, Am. J. Physiol. 105: 72, 1933. Google Scholar38. ChamberlainScudderSwemer FLJRL: Electrocardiographic changes associated with experimental alterations in blood potassium in cats, Am. Heart J. 18: 458, 1939. CrossrefGoogle Scholar39. VanattaMuirheadGrollman JEEA: Improvements on the artificial kidney: an experimental study of its application to dogs bilaterally nephrectomized or otherwise deprived of renal function, Am. J. Physiol. 156: 443, 1949. CrossrefMedlineGoogle Scholar40. Sharpey-Schafer EP: Potassium effects on T wave inversion in myocardial infarction and preponderance of a ventricle, Brit. Heart J. 5: 80, 1943. CrossrefMedlineGoogle Scholar41. LewisThornKoepfLorrance RAGWGFSS: The role of the adrenal cortex in acute anoxia, J. Clin. Investigation 21: 33, 1942. CrossrefMedlineGoogle Scholar42. EngelMartinTaylor FLSPH: On the relation of potassium to the neurological manifestations of hypocalcamic tetany, Bull. Johns Hopkins Hosp. 84: 285, 1949. MedlineGoogle Scholar43. MooreStewart NSHJ: The disappearance of intraventricular block occurring in uremia following the intravenous injection of hypertonic glucose solution, Am. Heart J. 5: 469, 1929-30. CrossrefGoogle Scholar44. MerrillThornWalterCallahanSmith JPGWCWEJLH: The use of an artificial kidney: I. Technique, J. Clin. Investigation 1950 (April). Google Scholar45. MerrillSmithCallahanThorn JPSEJGW: The use of an artificial kidney: II. Clinical aspects, J. Clin. Investigation 1950 (April). Google Scholar46. NicholsonSpaeth WMW: Some clinical manifestations of abnormal potassium metabolism, South. M. J. 42: 77, 1949. CrossrefMedlineGoogle Scholar47. Miller HC: Effect of the injection of sex hormones on serum and muscle electrolyte of rats, Endocrinology 32: 443, 1943. CrossrefGoogle Scholar48. TalbotButlerMacLachlan NBAMM: The effect of testosterone and allied compounds on the mineral, nitrogen and carbohydrate metabolism of a girl with Addison's disease, J. Clin. Investigation 22: 583, 1943. CrossrefMedlineGoogle Scholar49. KenyonKnowltonSandifordKochLatwin ATKIFCGM: A comparative study of the metabolic effects of testosterone propionate in normal men and women and in eunuchoidism, Endocrinology 26: 26, 1940. CrossrefGoogle Scholar50. Thompson WO: Androgen therapy, Ann. Int. Med. 30: 55, 1949. LinkGoogle Scholar51. KinsellMargenMichaelsSignorettiMcCallie LWSGDBDP: Studies in fat metabolism: I. Steroid hormonal effects upon blood ketones and other intermediate products of fat and protein metabolism, J. Clin. Endocrinol. 9: 671, 1949. Google Scholar52. Wilson DL: Personal communications. Google Scholar53. FeilDorfman MF: The influence of urinary cortin-like material on sodium and potassium metabolism, Endocrinology 37: 437, 1945. CrossrefMedlineGoogle Scholar54. BurnettBurrowsCommons CHRARR: Studies of alkalosis: I. Renal function during and following alkalosis resulting from pyloric obstruction, J. Clin. Investigation 29: 169, 1950. Burnett, C. H., Burrows, R. A., Commons, R. R., and Towery, B. T.: Studies of alkalosis: II. Electrolyte abnormalities in alkalosis resulting from pyloric obstruction, J. Clin. Investigation 29: 175, 1950. CrossrefMedlineGoogle Scholar55. LevineMerrillSomerville HDJPW: Advanced disturbances in the cardiac mechanism in potassium poisoning (to be published). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 24, 1950.From the Medical Clinic of the Peter Bent Brigham Hospital and the Department of Medicine, Harvard Medical School.This investigation was supported in part by a research grant from the Office of the Surgeon General, United States Army, in part by a grant from the National Heart Institute, United States Public Health Service, and in part by the Medical-Surgical Research Fund of the Peter Bent Brigham Hospital.†This work was done during the tenure of a Research Fellowship of the American Heart Association.‡Institute of Cardiology, London—Travelling Fellow in Cardiology, British Postgraduate Medical Federation (University of London).§Research Fellow in Medicine, Harvard Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDispelling myths and misconceptions about the treatment of acute hyperkalemiaSliding with the sines − fatal hyperkalemia: A case reportSpecific Cardiovascular Diseases and Competitive Sports Participation: ChannelopathiesManagement of hyperkalemia in the acutely ill patientAcute Management of HyperkalemiaTreatment of Severe Hyperkalemia: Confronting 4 FallaciesTreatment of hyperkalemia: something old, something newHyperkaliémie sévère ou menaçante : le diable est dans les détailsAcute Quadriplegia From HyperkalemiaBrugada SyndromeBrugada Syndrome: Report of the Second Consensus ConferenceEtiologies of left bundle branch block and correlations with hemodynamic and angiographic findingsBrugada syndrome and “Brugada sign”: Clinical spectrum with a guide for the clinicianThe use of the artificial kidney in the treatment of uremiaThe Na + , K + -pump and muscle contractilityProfound Hyperkalemia Without Electrocardiographic ManifestationsElectrocardiographic changes evoked by ajmaline in chronic chagas' disease without manifest myocarditisBundle Branch BlocksEffects of K+ and K+-induced polarization on (dV/dt)max, threshold potential, and membrane input resistance in guinea pig and cat ventricular myocardium.Dialysis in Acute Renal FailureHypokalaemia Occurring During Insulin-induced HypoglycaemiaIsohydric regulation of plasma potassium by bicarbonate in the ratEtiology of left bundle branch block. Hemodynamic and angiographic studiesBifascicular block induced by hyperkalemiaLeft Bundle Branch BlockCoronary Arteriographic Appearances in Patients with Left Bundle-Branch BlockUse of potassium, glucose and insulin in the treatment of myocardial infarctionAkutes NierenversagenPERITONEAL DIALYSIS IN ACUTE RENAL FAILURE FOLLOWING MALARIAThe management of acute reversible intrinsic renal failure.Potassium and the monophasic action potential, electrocardiogram, conduction and arrhythmiasExtra-, intrazellulärer Kaliumgehalt, Blutdruck und Ekg bei experimentellem Kaliumentzug mittels HämodialyseRADICAL OR CONSERVATIVE?EMERGENCY TREATMENT OF HYPERKALÆMIATHE BRIDGE BETWEEN NEUROLOGY AND PSYCHIATRYEMERGENCY TREATMENT OF HYPERKALÆMIAMetabolic myopathiesEffects of Hemodialysis and of Glucose-Insulin Administration on Plasma Potassium and on the ElectrocardiogramAcute renal failure in infancy and childhoodReversal of hyperkalemic cardiotoxicity with hypertonic salineThe Effect of Certain Ionic Interactions on the Water Metabolism of Chicks ,The Diagnosis and Treatment of Acute Renal FailureDie Grundstoffe der NahrungDie Bedeutung der QRS-Breite im EKG f�r die Beurteilung einer Hyperkali�mieHypotension accompanying ECG changes in two uremic patients with severe hypocalcemiaTreatment of the Oliguric Patient with a New Sodium-Exchange Resin and SorbitolManagement of Hyperkalemia with a Cation-Exchange ResinDie Künstliche Niere und ihre Anwendung bei akutem NierenversagenMineralstoffwechsel und KreislaufMineralstoffwechsel und KreislaufA Comparative Analysis of Molar Sodium Lactate and Other Agents in the Treatment of Induced Hyperkalemia in Nephrectomized DogsThe control of potassium intoxicationCARDIAC ARREST DURING ANAESTHESIA AND SURGERY With Special Reference to the ElectrocardiogramSevere Acidosis and Hyperpotassemia Treated with Sodium Bicarbonate InfusionCardiac aspects of renal diseaseStörungen des Kaliumstoffwechsels und ihre klinische BedeutungOn the Clinical Value of Electrocardiography in Renal FailureDie ?k�nstliche Niere?Dialyzable Currents of Injury in Potassium Intoxication Resembling Acute Myocardial Infarction or PericarditisAN ELECTROCARDIOGRAPHIC LOG OF RECURRENT HYPERKALEMIA IN A SEVERELY WOUNDED MAN*CARL M. PEARSON, M.D., MAURICE P. O'MEARA, M.D.The electrocardiographic effects of alterations in concentration of plasma chemicalsThe Treatment of Acute Traumatic Renal InsufficiencyRenal Function in Health and DiseasePost-traumatic renal insufficiency in military casualtiesStörungen im KaliumstoffwechselAlterations of potassium metabolism in pregnancyELECTROCARDIOGRAPHIC STUDIES WITH VARYING POTASSIUM PLASMA LEVELSElectrolyte abnormalities in epidemic hemorrhagic feverThe electrocardiogram in hemorrhagic feverHYPERPOTASSÆMIC PARALYSISOBSERVER ERRORPOTASSIUM INTOXICATION PRESUMABLY DUE TO ACUTE FUNCTIONAL ADRENOCORTICAL INSUFFICIENCY*JOHN H. FELTS JR., M.D.HYPERPOTASSÆMIC PARALYSISPHÆOCHROMOCYTOMAELECTROCARDIOGRAPHIC CHANGES DURING HEMODIALYSIS, WITH OBSERVATIONS ON CONTRIBUTION OF ELECTROLYTE DISTURBANCES TO DIGITALIS TOXICITY*ROBERT M. KOHN, M.D., JOHN E. KILEY, M.D.HYPERPOTASSÆMIC PARALYSISSERUM POTASSIUM PATTERNS IN ANURIA AND OLIGURIA*JAMES HOPPER JR., BRIAN P. O'CONNELL, HELLA R. FLUSSThe effect of changes in concentration of cations on the electrocardiogram of the isolated perfused heart“Tent-shaped” T waves of normal amplitude in potassium intoxicationChronic Pyelonephritis Simulating Adrenocortical InsufficiencyThe Potassium Factor in Deep BurnsAdvanced Disturbances of the Cardiac Mechanism in Potassium Intoxication in Man 1 October 1950Volume 33, Issue 4Page: 797-830KeywordsExcretionHeartHospital medicineIntoxicationMedical servicesPotassiumResearch fundingResearch grantsSurgeonsToxicity ePublished: 1 December 2008 Issue Published: 1 October 1950 PDF downloadLoading ...
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
聪明涵山发布了新的文献求助10
4秒前
Czy完成签到,获得积分10
5秒前
呆萌冰绿发布了新的文献求助10
5秒前
6秒前
6秒前
Merlin完成签到,获得积分10
6秒前
冰魂应助XIAOBAI采纳,获得10
7秒前
化工牛马发布了新的文献求助10
7秒前
Hello应助干净山柳采纳,获得30
7秒前
乐乐应助炙热乘云采纳,获得10
7秒前
跳跃一手完成签到,获得积分10
8秒前
11秒前
无算浮白发布了新的文献求助10
12秒前
扶摇直上九万里完成签到 ,获得积分10
12秒前
yang发布了新的文献求助10
12秒前
良辰应助zcw采纳,获得10
14秒前
15秒前
jianjianjiang完成签到,获得积分10
15秒前
17秒前
铅笔完成签到,获得积分10
18秒前
白给完成签到,获得积分10
18秒前
19秒前
干净山柳发布了新的文献求助30
19秒前
20秒前
Jasper应助汉堡采纳,获得10
21秒前
炙热乘云发布了新的文献求助10
21秒前
23秒前
研友_VZG7GZ应助卢佳伟采纳,获得10
23秒前
小明同学发布了新的文献求助10
24秒前
花椒鱼发布了新的文献求助10
25秒前
化工牛马发布了新的文献求助30
25秒前
墨墨发布了新的文献求助10
25秒前
33秒前
liao完成签到,获得积分10
33秒前
33秒前
34秒前
冰魂应助小高爱科研采纳,获得10
34秒前
二由发布了新的文献求助10
36秒前
高分求助中
Encyclopedia of Mathematical Physics 2nd edition 888
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
Peking Blues // Liao San 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3803560
求助须知:如何正确求助?哪些是违规求助? 3348491
关于积分的说明 10338705
捐赠科研通 3064604
什么是DOI,文献DOI怎么找? 1682637
邀请新用户注册赠送积分活动 808381
科研通“疑难数据库(出版商)”最低求助积分说明 764038