Feasibility Study of Vascularized Composite Urinary Bladder Allograft Transplantation in a Cadaver Model

No AccessJournal of UrologyAdult Urology1 Jul 2021Feasibility Study of Vascularized Composite Urinary Bladder Allograft Transplantation in a Cadaver ModelThis article is commented on by the following:Editorial CommentEditorial Comment Patricio C. Gargollo, Mohamed E. Ahmed, Mikel Prieto, Mohit Butaney, Carl H. Cramer, Vidhu Joshi, Julie K. Heimbach, and Candace F. Granberg Patricio C. GargolloPatricio C. Gargollo *Correspondence: Department of Urology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905 telephone: 507-284-3249; E-mail Address: [email protected] Department of Urology, Mayo Clinic, Rochester, Minnesota , Mohamed E. AhmedMohamed E. Ahmed Department of Urology, Mayo Clinic, Rochester, Minnesota , Mikel PrietoMikel Prieto Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota , Mohit ButaneyMohit Butaney Department of Urology, Mayo Clinic, Rochester, Minnesota , Carl H. CramerCarl H. Cramer Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota , Vidhu JoshiVidhu Joshi Department of Urology, Mayo Clinic, Rochester, Minnesota , Julie K. HeimbachJulie K. Heimbach Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota , and Candace F. GranbergCandace F. Granberg Department of Urology, Mayo Clinic, Rochester, Minnesota View All Author Informationhttps://doi.org/10.1097/JU.0000000000001699AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The purpose of this study was to establish the feasibility of performing a urinary bladder vascularized composite allograft transplantation for either bladder augmentation or neobladder creation. Materials and Methods: Six adult cadavers were studied. Cadavers were excluded for any previous pelvic surgery, radiation, vascular surgery or history of pelvic malignancy. An intravascular colored silicone and barium mixture was injected and both computerized tomography scans and gross dissections were performed. Contrast enhanced computerized tomography imaging was used to delineate urinary bladder vascular anatomy variability. Bladders were explanted en bloc from 2 cadavers with bilateral vascular pedicles based on the external iliac vessels and "transplanted" to replicate a bladder transplant. Results: Contrast enhanced 3-D-computerized tomography reconstructions and cadaver dissections revealed distal vascular variability with proximal blood supply based primarily on the internal iliac artery. Urinary bladder vascularized composite allograft transplantation was successfully performed during 2 mock transplants with the vascular anastomosis done to the recipient external iliac artery and vein. 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We are also thankful to our colleagues in the anatomy department and biomedical science department at Mayo Clinic who provided expertise that greatly assisted our study.MetricsAuthor Information Patricio C. Gargollo Department of Urology, Mayo Clinic, Rochester, Minnesota *Correspondence: Department of Urology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905 telephone: 507-284-3249; E-mail Address: [email protected] More articles by this author Mohamed E. Ahmed Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author Mikel Prieto Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota Financial and/or other relationship with Mayo Clinic. More articles by this author Mohit Butaney Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author Carl H. Cramer Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota More articles by this author Vidhu Joshi Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author Julie K. Heimbach Division of Transplantation Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota More articles by this author Candace F. Granberg Department of Urology, Mayo Clinic, Rochester, Minnesota More articles by this author Expand All Advertisement Loading ...