病毒准种
乙型肝炎病毒
DNA测序
病毒学
生物
基因型
基因组
深度测序
乙型肝炎
病毒
医学
计算生物学
丙型肝炎病毒
遗传学
基因
作者
Selene García-García,María Francesca Cortese,Francisco Rodríguez-Algarra,David Tabernero,Ariadna Rando-Segura,Josep Quer,María Buti,Francisco Rodríguez‐Frías
标识
DOI:10.1080/14737159.2021.1913055
摘要
Hepatitis B virus (HBV) causes a complex and persistent infection with a major impact on patients health. Viral-genome sequencing can provide valuable information for characterizing virus genotype, infection dynamics and drug and vaccine resistance.This article reviews the current literature to describe the next-generation sequencing progress that facilitated a more comprehensive study of HBV quasispecies in diagnosis and clinical monitoring.HBV variability plays a key role in liver disease progression and treatment efficacy. Second-generation sequencing improved the sensitivity for detecting and quantifying mutations, mixed genotypes and viral recombination. Third-generation sequencing enables the analysis of the entire HBV genome, although the high error rate limits its use in clinical practice.
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