A Review

The next-generation sequencing (NGS) is very important for genetics. One of the most popular sequencing approaches is exome sequencing, which is a lower cost and high-throughput sequencing method. Here, this study first reviews the history of next-generation sequencing and exome sequencing. And then, it illustrates four genetic variants in tumor as well as the application of the exome sequencing for cancer research. Finally, it discusses the current analysis methods for exome sequencing and related tools.