P695Oral antibiotics increase atherosclerosis independently of diet

Conclusions: Our studies identified that HDC+CD11b+ myeloid cells increase in circulation in response to hypercholesterolemia and contribute to foam cell formation in atherosclerosis.In vivo and in vitro studies demonstrated that histamine could promote the macrophage differentiation and foam cell formation via the STAT6 signal.Modulation of histamine and STAT6-signaling may represent an attractive therapeutic strategy for the prevention or treatment of atherosclerosis.