Cisplatin and 5-fluorouracil for advanced locoregional and metastatic squamous cell carcinoma of the skin

CancerVolume 67, Issue 8 p. 2030-2032 Clinical TrialFree Access Cisplatin and 5-fluorouracil for advanced locoregional and metastatic squamous cell carcinoma of the skin Tawfiq Khansur MD, Corresponding Author Tawfiq Khansur MD University of Mississippi School of Medicine and Department of Veterans Affairs Medical Center, Jackson, MississippiUniversity of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216===Search for more papers by this authorAlan Kennedy MD, Alan Kennedy MD University of Mississippi School of Medicine and Department of Veterans Affairs Medical Center, Jackson, MississippiSearch for more papers by this author Tawfiq Khansur MD, Corresponding Author Tawfiq Khansur MD University of Mississippi School of Medicine and Department of Veterans Affairs Medical Center, Jackson, MississippiUniversity of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216===Search for more papers by this authorAlan Kennedy MD, Alan Kennedy MD University of Mississippi School of Medicine and Department of Veterans Affairs Medical Center, Jackson, MississippiSearch for more papers by this author First published: 15 April 1991 https://doi.org/10.1002/1097-0142(19910415)67:8<2030::AID-CNCR2820670803>3.0.CO;2-KCitations: 94AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Seven patients with advanced locoregional or metastatic squamous cell carcinoma of the skin were treated with cis-daimminedichloroplatin (cisplatin) and 5-fluorouracil (5-FU). Responses were seen in six of seven patients (three partial responses [PR] and three complete responses [CR]). One patient is alive and disease-free at 2 years. These results indicate that cisplatin and 5-FU is an effective combination regimen that should be used in future clinical trials in squamous cell carcinoma of the skin. References 1 Stoll HL Jr, Schwartz RA. Squamous cell carcinoma. In: TB Fitzpatrick, AZ Eisen, LC Wolff et al., eds. Dermatology General Medicine, ed. 3. New York: McGraw Hill, 1987; 746–758. 2 Epstein E, Epstein MM, Bragg K, Linden G. Metastasis from squamous cell carcinoma of the skin. Arch Dermatol 1986; 97: 245–251. 3 Moller R, Reyman F, Hou-Jensen K. Metastasis in dermatological patients with squamous cell carcinoma. Arch Dermatol 1979; 115: 703–705. 4 Fitzgerald GB, Wick MM. Comparison of the inhibitory effects of hydroxyurea 5-Fluorodeoxyuridine 3,4-Dihydroxy benzylamine, and methotrexate on human squamous cell carcinoma. J Invest Dermatol 1987; 88: 66–70. 5 Nagase M, Nomura T, Nakajima T. Effects of intralesional versus IP administration of cisplatin on squamous cell carcinoma of mice. Cancer Treat Rep 1982; 71: 825–829. 6 Salem P, Hall SW, Benjamin RS. Clinical phase I-II study of Cis-Dichloro-Diammineplatinum (II) given by continuous IV infusion. Cancer Treat Rep 1976; 62: 1553–1556. 7 Scanlon KY, Newman EM, Priest DG. Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian cancer cells. Proc Natl Acad Sci U S A 1986; 83: 8923–8925. 8 Guthrie TH, Porbsky ES. Successful systemic chemotherapy of advanced squamous and basal cell carcinoma of the skin with Cis-diamminedichloroplatinum III and doxorubicin. Laryngoscope 1982; 92: 1298–1299. 9 Hallerstein S, Rosen S, Kies M, Tsang T, Shaw J. Dichloro-Diammineplatinum and 5-FU combined chemotherapy of epidermoid esophageal cancer (Abstr). Proc Am Soc Clin Oncol 1983; 2: 127. 10 Kish J, Drelichman A, Jacobs J et al. Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 1982; 66: 471–474. 11 Weiman TJ, Shively EH, Wookcock EM. Responsiveness of metastatic basal cell carcinoma to chemotherapy. Cancer 1983; 52: 1583–1585. 12 Guthrie TH, Porubsky ES, Luxenburg NM, Shah KJ, Wurtz KL, Watson PR. Cisplatin-based chemotherapy in advanced basal and squamous cell carcinoma of the skin: Results in 28 patients including 13 patients receiving multimodality therapy. J Clin Oncol 1990; 8: 342–346. 13 Roberts NJ, Govil M, Clark J, O'Connor T, Wagner H, Ervin T. Combination chemotherapy for SI (Abstr). Proc Am Soc Clin Oncol 1985; 4: 138. Citing Literature Volume67, Issue815 April 1991Pages 2030-2032 ReferencesRelatedInformation