Naltrexone for the Management of Alcohol Dependence

A 44-year-old businessman presents with clinical evidence of alcohol dependence and acknowledges excessive drinking. The use of naltrexone is recommended. Naltrexone is an opioid-blocking agent that inhibits reward signaling in the brain and reduces alcohol craving. Hepatotoxicity has been reported with naltrexone. This drug should not be used in patients who are physically dependent on opiates.