浆母细胞性淋巴瘤
淋巴瘤
医学
口腔粘膜
免疫抑制
病理
人类免疫缺陷病毒(HIV)
皮肤病科
免疫学
作者
Damien Mikael Hansra,Naomi Montague,Alexandra Stefanovic,Ikechukwu Immanuel Akunyili,Arash Harzand,Yasodha Natkunam,Margarita De La Ossa,Gerald E. Byrne,Izidore S. Lossos
标识
DOI:10.1309/ajcpjh6keusecqlu
摘要
Abstract Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non–HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.
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