Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men

番茄红素 叶黄素 医学 内科学 玉米黄质 类胡萝卜素 相对风险 心肌梗塞 四分位数 视黄醇 内分泌学 维生素 置信区间 化学 食品科学
作者
Howard D. Sesso,Julie E. Buring,Edward P. Norkus,J. Michael Gaziano
出处
期刊:The American Journal of Clinical Nutrition [Oxford University Press]
卷期号:81 (5): 990-997 被引量:141
标识
DOI:10.1093/ajcn/81.5.990
摘要

Emerging evidence suggests a possible role of lycopene in the primary prevention of cardiovascular disease (CVD).We examined whether plasma lycopene concentrations in the Physicians' Health Study were associated with CVD in a prospective, nested, case-control design.Baseline blood samples were collected starting in 1996. During a mean follow-up of 2.1 y, we identified 499 cases of CVD (confirmed myocardial infarction, stroke, CVD death, or revascularization procedures) and an equal number of men free of CVD and matched for age (x: 69.7 y), follow-up time, and smoking status. We collected self-reported coronary disease risk factors and measured plasma carotenoids, retinol, lipids, and C-reactive protein.In matched analyses with additional adjustment for plasma total cholesterol and randomized treatment, the relative risks (RRs) of CVD for men in the lowest to highest quartiles of plasma lycopene were 1.00 (reference), 0.92, 1.04, and 0.95 (P for linear trend = 0.93). With multivariate adjustment, the RRs of total CVD were 1.00 (reference), 1.08, 0.94, and 1.03 (P for linear trend = 0.98). For important vascular events (241 cases), excluding revascularization procedures, the multivariate RRs remained nonsignificant (P for linear trend = 0.50). Adding plasma carotenoids, lipids, or C-reactive protein to multivariate models had a minimal effect on the RRs of total CVD for plasma lycopene. Compared with lycopene, higher concentrations of plasma lutein/zeaxanthin and retinol suggested a moderate increase in CVD risk, whereas no association was found for beta-cryptoxanthin, alpha-carotene, and beta-carotene.Higher plasma lycopene concentrations were not associated with the risk of CVD in this study of older men. Further evaluation in diverse populations is necessary.
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