生物
中心公差
自身免疫
自我容忍
免疫学
免疫耐受
抗原呈递
细胞生物学
抗原
神经科学
T细胞
免疫系统
作者
Bruno Kyewski,Ludger Klein
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2006-04-01
卷期号:24 (1): 571-606
被引量:679
标识
DOI:10.1146/annurev.immunol.23.021704.115601
摘要
Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells (mTECs). TRA expression in mTECs mirrors virtually all tissues of the body, irrespective of developmental or spatio-temporal expression patterns. This review summarizes current knowledge on the cellular and molecular regulation of TRA expression in mTECs, outlines relevant mechanisms of antigen presentation and modes of tolerance induction, and discusses implications for the pathogenesis of autoimmune diseases and other biological processes such as fertility, pregnancy, puberty, and tumor defense.
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