细胞融合
生物
癌细胞
癌症
细胞
肿瘤病毒
基因组不稳定性
病毒学
病毒
癌症研究
细胞生物学
遗传学
DNA
DNA损伤
作者
Dominik M. Duelli,Yuri Lazebnik
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2007-12-01
卷期号:7 (12): 968-976
被引量:186
摘要
The ability to fuse cells is shared by many viruses, including common human pathogens and several endogenous viruses. Here we will discuss how cell fusion can link viruses to cancer, what types of cancers it can affect, how the existence of this link can be tested and how the hypotheses that we propose might affect the search for human oncogenic viruses. In particular, we will focus on the ability of cell fusion that is caused by viruses to induce chromosomal instability, a common affliction of cancer cells that has been thought to underlie the malignant properties of cancerous tumours.
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