糖尿病性视网膜病变
糖尿病
生物
生物信息学
生物标志物
血管生成
小RNA
发病机制
视网膜病变
重症监护医学
内科学
医学
内分泌学
免疫学
癌症研究
基因
遗传学
作者
Erfan Rezazadeh-Gavgani,Mobina Oladghaffari,Shirin Bahramian,Reza Majidazar,Sanam Dolati
出处
期刊:Gene
[Elsevier]
日期:2023-04-01
卷期号:859: 147212-147212
被引量:2
标识
DOI:10.1016/j.gene.2023.147212
摘要
Diabetes mellitus (DM) has grown in attention in recent years as a result of its debilitating complications and chronic disabilities. Diabetic retinopathy (DR) is a chronic microvascular complication of DM and is considered as the primary reason for blindness in adults. Early diagnosis of diabetes complications along with targeted therapy options are critical in avoiding morbidity and mortality associated with complications of diabetes. miR-21 is an important and widely studied non-coding-RNA (ncRNA) with considerable roles in various pathologic conditions including diabetic complications. miR-21 is one of the most elevated miRNAs in response to hyperglycemia and its role in angiogenesis is a major culprit of a wide range of disorders including DR. The main role of miR-21 in DR pathophysiology is believed to be through regulating angiogenesis in retina. This article aims to outline miR-21 biogenesis and distribution in human body along with discussions about its role in DR pathogenesis and its biomarker value in order to facilitate understanding of the new characteristics of miR-21 in DR management.
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