神经炎症
长时程增强
冲程(发动机)
小胶质细胞
医学
缺血性中风
材料科学
神经科学
内科学
心脏病学
炎症
缺血
心理学
机械工程
工程类
受体
作者
Miki Tanaka,Tomoaki Okuda,Kouichi Itoh,Nami Ishihara,Ami Oguro,Yoshiaki Fujii‐Kuriyama,Yu Nabetani,Megumi Yamamoto,Christoph F.A. Vogel,Yasuhiro Ishihara
标识
DOI:10.1186/s12989-023-00517-x
摘要
A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported that microglial activation in ischemic stroke plays an important role in neuronal damage. In this study, we investigated the effects of urban aerosol exposure on neuroinflammation and the prognosis of ischemic stroke using a mouse photothrombotic model.When mice were intranasally exposed to CRM28, urban aerosols collected in Beijing, China, for 7 days, microglial activation was observed in the olfactory bulb and cerebral cortex. Mice exposed to CRM28 showed increased microglial activity and exacerbation of movement disorder after ischemic stroke induction. Administration of core particles stripped of attached chemicals from CRM28 by washing showed less microglial activation and suppression of movement disorder compared with CRM28-treated groups. CRM28 exposure did not affect the prognosis of ischemic stroke in null mice for aryl hydrocarbon receptor, a polycyclic aromatic hydrocarbon (PAH) receptor. Exposure to PM2.5 collected at Yokohama, Japan also exacerbated movement disorder after ischemic stroke.Particle matter in the air is involved in neuroinflammation and aggravation of the prognosis of ischemic stroke; furthermore, PAHs in the particle matter could be responsible for the prognosis exacerbation.
科研通智能强力驱动
Strongly Powered by AbleSci AI