内分泌学
内科学
脂肪细胞
脂肪组织
能量稳态
白色脂肪组织
葡萄糖稳态
激素
生物
脂质代谢
碳水化合物代谢
平衡
脂肪生成
胰岛素
胰岛素抵抗
医学
肥胖
作者
Yiruo Ma,Siyi Shen,Ying Yan,Shengjie Zhang,Shengnan Liu,Zhili Tang,Jing Yu,Mei Ma,Zhoumin Niu,Zhuoyang Li,Yuting Wu,Lin Zhao,Zhiqiang Lu,Chunchun Wei,Weiping J. Zhang,Ying Xue,Qiwei Zhai,Yu Li,Cheng Hu,Jingjing Jiang
出处
期刊:Diabetes
[American Diabetes Association]
日期:2023-02-01
卷期号:72 (5): 562-574
被引量:28
摘要
How thyroid hormone (TH) achieves its diverse biological activities in the regulation of metabolism is not fully understood. Whether TH regulates systemic metabolic homeostasis via its action on white adipose tissue is unclear. Adipocyte TH receptor (TR) β mediates the triiodothyronine effect on multiple metabolic pathways by targeting glucose-responsive lipogenic transcription factor in white adipose tissue; mice lacking adipocyte TRβ are susceptible to high-fat diet-induced metabolic abnormalities. TRβ in white adipocytes controls intracellular and systemic metabolism and may be a potential target for metabolic diseases.
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