Juxtacortical White Matter Staging as a Correlate of Progression in Alzheimer Disease

HomeRadiologyVol. 317, No. 1 PreviousNext Reviews and CommentaryEditorialJuxtacortical White Matter Staging as a Correlate of Progression in Alzheimer DiseaseMenno M. Schoonheim1 Menno M. Schoonheim1 Author Affiliations1MS Center Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, De Boelelaan 1118, 1081HV, Amsterdam, The NetherlandsAddress correspondence to: the author (email: [email protected]).Menno M. Schoonheim1 Published Online:Oct 7 2025https://doi.org/10.1148/radiol.252559See also the article by Zhang and Yang et al in this issue.MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In References1. Dadar M, Manera AL, Ducharme S, Collins DL. White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia. Neurobiol Aging 2022;111:54–63. Medline Google Scholar2. Chen Y, Wang Y, Song Z, Fan Y, Gao T, Tang X. Abnormal white matter changes in Alzheimer's disease based on diffusion tensor imaging: a systematic review. Ageing Res Rev 2023;87:101911. Medline Google Scholar3. Young AL, Marinescu RV, Oxtoby NP, et al; Alzheimer's Disease Neuroimaging Initiative (ADNI). Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with subtype and stage inference. Nat Commun 2018;9(1):4273. Medline Google Scholar4. Estarellas M, Oxtoby NP, Schott JM, Alexander DC, Young AL. Multimodal subtypes identified in Alzheimer's Disease Neuroimaging Initiative participants by missing-data-enabled subtype and stage inference. Brain Commun 2024;6(4):fcae219. Medline Google Scholar5. Zhang J, Yang X, Wang Y, et al. Identifying distinct spatiotemporal patterns of juxtacortical microstructure in Alzheimer disease using diffusion MRI–derived free water fraction. Radiology 2025;317(1):e243423. Google Scholar6. Wattjes MP, Ciccarelli O, Reich DS, et al; North American Imaging in Multiple Sclerosis Cooperative MRI guidelines working group. 2021 MAGNIMS-CMSC-NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis. Lancet Neurol 2021;20(8):653–670. Medline Google Scholar7. Lin CP, Frigerio I, Boon BDC, et al. Structural (dys)connectivity associates with cholinergic cell density in Alzheimer's disease. Brain 2022;145(8):2869–2881. Medline Google Scholar8. Nasrabady SE, Rizvi B, Goldman JE, Brickman AM. White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes. Acta Neuropathol Commun 2018;6(1):22. Medline Google Scholar9. Veale T, Malone IB, Poole T, et al. Loss and dispersion of superficial white matter in Alzheimer's disease: a diffusion MRI study. Brain Commun 2021;3(4):fcab272. Medline Google Scholar10. van Loenhoud AC, van der Flier WM, Wink AM, et al; Alzheimer's Disease Neuroimaging Initiative. Cognitive reserve and clinical progression in Alzheimer disease: a paradoxical relationship. Neurology 2019;93(4):e334–e346. Medline Google ScholarArticle HistoryReceived: Aug 16 2025Revision requested: Sept 18 2025Revision received: Sept 18 2025Accepted: Sept 22 2025Published online: Oct 07 2025 FiguresReferencesRelatedDetailsAccompanying This ArticleIdentifying Distinct Spatiotemporal Patterns of Juxtacortical Microstructure in Alzheimer Disease Using Diffusion MRI–derived Free Water FractionOct 7 2025Radiology Vol. 317, No. 1 Metrics Altmetric Score PDF download