Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

neurons rapidly reduces heart rate, attenuates hypertensive responses, and accelerates blood pressure recovery. Conversely, their inhibition exacerbates blood pressure elevations, delays recovery to baseline, and impairs locomotor performance. Correlation analyses reveal a significant negative relationship between blood pressure fluctuations and locomotor metrics, such as total running distance and high-speed locomotion duration, underscoring the interdependence of cardiovascular stability and motor function. These findings position the PSTN as a critical central command hub, offering novel insights into the neural circuits governing cardiovascular homeostasis and locomotion, with potential implications for targeted neuromodulatory interventions in hypertension.