乳腺癌
生物
核糖体蛋白
癌变
转录组
临床意义
生物标志物
癌症
基因
计算生物学
生物信息学
基因表达
癌症研究
肿瘤科
医学
遗传学
病理
核糖核酸
核糖体
作者
Alexandre Luiz Korte de Azevedo,Talita Helen Bombardelli Gomig,Igor Samesima Giner,Michel Batista,Fabrício Klerynton Marchini,Rubens Silveira de Lima,Cı́cero de Andrade Urban,Ana Paula Martins Sebastião,Iglenir João Cavalli,Enilze Maria de Souza Fonseca Ribeiro
标识
DOI:10.1016/j.compbiolchem.2022.107746
摘要
Several evidence has demonstrated the involvement of the ribosomal proteins (RPs) in many malignancies, however, the function and clinical relevance of the RPs in breast cancer remains unclear. The present study aims to contribute to the understanding of the role of the RPs in breast tumorigenesis and its clinical implications in the field of biomarker discovery and outcome prediction. We investigated the proteomic and transcriptomic expression of the RPs in non-tumor and tumor tissues of different breast cancer subtypes, and integrated bioinformatics approaches and online databases to comprehensively evaluate the potential functions, regulatory networks, mutational landscape, and prognostic values of the ribosomal proteins in breast cancer. Our results show that 33 RPs have deregulated expression in breast cancer and its subtypes and that 26 RPs have potential as prognostic markers in a subtype-dependent way, with mutations in RP genes being frequent in breast tumors and related to overall survival and relapse-free status. Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir-4668-3p as regulators of the RPs expression in breast cancer. The RPs were associated with several clinicopathological parameters of breast cancer and predicted to be involved in ribosomal-independent mechanisms such as regulation of the SLITS-ROBO pathway. This study comprehensively investigated the ribosomal proteins in breast cancer, suggesting that the RPs have clinical potential as biomarkers of diagnostic and prognostic, also providing an in-depth view of the RPs significance in breast cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI