纤维化
医学
细胞外基质
肾
病理
肾脏疾病
内科学
生物
细胞生物学
作者
K Wang,Qiuling Liao,Xiang Chen
出处
期刊:Heliyon
[Elsevier]
日期:2023-08-01
卷期号:9 (8): e18723-e18723
被引量:1
标识
DOI:10.1016/j.heliyon.2023.e18723
摘要
Abstract
Renal fibrosis is a common result for various chronic kidney diseases developing to the end stage. It is a pathological process characterized by the destruction of normal kidney structure and the subsequent replacement with fibrous tissue, which primarily involves fibroblast proliferation and extracellular matrix deposition. Obstruction is a common cause of renal fibrosis, and obstructive renal fibrosis is a common disease in urology. Obstructive renal fibrosis, characterized by its insidious onset, is the result of a complex interplay of multiple factors. These factors encompass renal tubular epithelial cell injury, the presence of a hypoxic microenvironment in affected kidney tissue, inflammatory cell infiltration, release of inflammatory mediators, and the release of renal fibrosis growth factors, among others. This paper reviews the research progress on the mechanism and treatment of renal interstitial fibrosis.
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