肽
异构化
环肽
光异构化
生物物理学
单体
小泡
自组装
纳米管
化学
材料科学
氨基酸
纳米技术
生物化学
膜
有机化学
碳纳米管
聚合物
生物
催化作用
作者
Marcos Vilela-Picos,Federica Novelli,Antía Pazó,Alejandro Méndez‐Ardoy,Giulia Marafon,Manuel Amorín,Alessandro Moretto,Juan R. Granja
出处
期刊:Chem
[Elsevier]
日期:2023-11-01
卷期号:9 (11): 3365-3378
标识
DOI:10.1016/j.chempr.2023.10.005
摘要
Cyclic peptides containing a β-unsaturated amino acid are programmed to switch between monomeric form and self-assembled peptide nanotube structures upon light irradiation. The process is triggered by the reversible E-Z isomerization of the unsaturated β-amino acid that forces the peptide to swap from the folded (unassembled) to the flat conformation (assembled). The process is also tuned by the pH media, which provides a double checkpoint control in the molecular assembly of the peptide nanotubes. The light-driven assembly process can be triggered in a confined environment, and the resulting nanotubes allow the inter-vesicle communication, providing droplets with self-fusiogenic properties.
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