声动力疗法
免疫检查点
免疫系统
癌症研究
细胞凋亡
免疫疗法
程序性细胞死亡
癌症免疫疗法
化学
医学
免疫学
生物化学
作者
Yuqi Yang,Jun Ge,Guangqiang Li,Huali Lei,Linfu Chen,Yuehan Gong,Xiaoyan Zhong,Li Wang,Yizhi Dai,Wei Tang,Jun Zou,Yuan Cheng,Zhuang Liu,Liang Cheng
出处
期刊:Nano Today
[Elsevier]
日期:2022-10-01
卷期号:46: 101585-101585
被引量:16
标识
DOI:10.1016/j.nantod.2022.101585
摘要
Sonodynamic therapy (SDT)-induced immunogenic cell death (ICD) features the potential for cancer therapy. However, SDT alone is weak to trigger robust ICD. Herein, PEGylation manganese-doping titanium disulfide nanosheets (PEG-Mn: TiSx NSs, abbreviated as MnTiS-PEG) are fabricated as a kind of cascade bioreactor for sequential gas therapy (GT)-enhanced SDT. MnTiS-PEG could release H2S gas to first induce cell apoptosis via mitochondria damage, accompanied by an oxidative degradation that would boost the efficacy of the sonodynamic effects under US irradiation, which is much superior to the commercial TiO2. With Mn2+ releasing, such cascade process could further trigger satisfactory ICD and enhance dendric cells (DCs) maturation. In vitro and in vivo results illustrate the outstanding outcomes of such sequential GT-SDT along with a series of immune responses. Considering the possible immune tolerance, anti-programmed cell death-1 (αPD-L1), an immune checkpoint inhibitor, is employed subsequently to further inhibit tumor growth. It is found that this combination displays not only an excellent therapeutical performance on the primary tumors, but also an abscopal effect at the same time. Briefly, our work establishes a cascade bioreactor for the programmed GT-SDT with satisfactory immune responses, which provides an effective method for enhancing SDT and immunotherapy.
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