噬菌体疗法
生物
噬菌体
抗菌剂
纳米载体
微生物群
噬菌体展示
免疫系统
计算生物学
微生物学
免疫学
药品
生物信息学
药理学
遗传学
抗体
大肠杆菌
基因
作者
Geng Zou,Lin He,Jing Rao,Zhiyong Song,Hongwu Du,Runze Li,Wenjing Wang,Yang Zhou,Lu Liang,Huanchun Chen,Jinquan Li
出处
期刊:Fems Microbiology Reviews
[Oxford University Press]
日期:2023-07-01
卷期号:47 (4)
被引量:1
标识
DOI:10.1093/femsre/fuad042
摘要
Phage therapy has re-emerged as a promising solution for combating antimicrobial-resistant bacterial infections. Increasingly, studies have revealed that phages possess therapeutic potential beyond their antimicrobial properties, including regulating the gut microbiome and maintain intestinal homeostasis, as a novel nanocarrier for targeted drug delivery. However, the complexity and unpredictability of phage behavior during treatment pose a significant challenge in clinical practice. The intricate interactions established between phages, humans, and bacteria throughout their long coexistence in the natural ecosystem contribute to the complexity of phage behavior in therapy, raising concerns about their efficacy and safety as therapeutic agents. Revealing the mechanisms by which phages interact with the human body will provide a theoretical basis for increased application of promising phage therapy. In this review, we provide a comprehensive summary of phage-mammal interactions, including signaling pathways, adaptive immunity responses, and phage-mediated anti-inflammatory responses. Then, from the perspective of phage-mammalian immune system interactions, we present the first systematic overview of the factors affecting phage therapy, such as the mode of administration, the physiological status of the patient, and the biological properties of the phage, to offer new insights into phage therapy for various human diseases.
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