组蛋白乙酰转移酶
酰化
乙酰化
组蛋白
乙酰转移酶
生物
计算生物学
化学
生物化学
DNA
催化作用
基因
作者
Nan Li,Clark Hamor,Young Jun An,Licheng Zhu,Yong Gong,Yukimatsu Toh,Yusong R. Guo
出处
期刊:Acta Materia Medica
[Compuscript, Ltd.]
日期:2023-01-01
卷期号:2 (2)
标识
DOI:10.15212/amm-2023-0010
摘要
Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal acylation is strongly associated with various diseases, such as cancer. Thus, histone acetyltransferases (HATs), the “writers” that catalyze histone acylation, are promising targets for cancer treatment. Rapid developments in structural biology and artificial intelligence have facilitated the development of drugs targeting HATs. To provide new ideas for exploring novel HAT modifiers with high efficiency and selectivity, this article reviews the relationships between acylation and diseases, illustrates HAT catalytic mechanisms through structural biology, and summarizes research progress in HAT modifiers.
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