甲基丙烯酸酯
乙二醇
高分子化学
原子转移自由基聚合
共聚物
纳米载体
化学
聚合
侧链
聚合物
材料科学
药物输送
有机化学
作者
Hongbing Liu,Zheng Guo,Wei Ma,Shuang Li,Dun Wang,Zhi Zheng,Ying Liu,Cui‐Yun Yu,Hua Wei
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2023-07-11
卷期号:12 (8): 1025-1030
被引量:9
标识
DOI:10.1021/acsmacrolett.3c00265
摘要
Cyclic polymers with cleavable backbones triggered by either external or internal stimuli can realize simultaneous extracellular stability and intracellular destabilization of cyclic polymer-based nanocarriers but remain seldom reported. To this end, we prepared herein cyclic-ONB-P(OEGMA-st-DMAEMA) (c-ONB-P(OEGMA-st-DMAEMA)) with a light-cleavable junction in the polymer backbone based on oligo (ethylene glycol) monomethyl ether methacrylate (OEGMA) and N,N-dimethylaminoethyl methacrylate (DMAEMA) using a light-cleavable atom transfer radical polymerization (ATRP) initiator containing an o-nitrobenzyl (ONB) ester group. Together with the pH-sensitivity of DMAEMA, c-ONB-P(OEGMA-st-DMAEMA) shows a light-cleavable mainchain and pH-sensitive side chains. Notably, doxorubicin (DOX)-loaded c-ONB-P(OEGMA4-st-DMAEMA38) (C2) micelles mediated an IC50 value of 2.28 μg/mL in Bel-7402 cells, which is 1.7-fold lower than that acquired without UV irradiation. This study thus reported the synthesis of a cyclic copolymer with a UV-cleavable backbone and uncovered the effects of topological modulation on the in vitro controlled release properties of cyclic polymers.
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