Regulable Polyelectrolyte‐Surfactant Complex for Antibacterial Biomedical Catheter Coating via a Readily Scalable Route

Abstract Constructing multifunctional surfaces is one of the practical approaches to address catheter‐related multiple complications but is generally time‐consuming and substrate‐dependent. Herein, a novel anti‐adhesion, antibacterial, low friction, and robustness coating on medical catheters are developed via a universal and readily scalable method based on a regulable polyelectrolyte surfactant complex. The complex is rapidly assembled in one step by electrostatic and hydrophobic interactions between organosilicon quaternary ammonium surfactant (N+Si) and adjustable polyelectrolyte with cross‐linkable, anti‐adhesive, and anionic groups. The alcohol‐soluble feature of the complex is conducive to the rapid formation of coatings on any medical device with arbitrary shapes via dip coating. Different from the conventional polyelectrolyte–surfactant complex coating, the regulated complex coating with nonleaching mode could be stable in harsh conditions (high concentration salt solution, organic reagents, etc.) because of the cross‐linked structure while improving the biocompatibility and reducing the adhesion of various bacteria, proteins, and blood cells. The coated catheter exhibits good antibacterial infection in vitro and in vivo, owing to the synergistic effect of N+Si and zwitterionic groups. Therefore, the rationally designed complex supplies a facile coating approach for the potential development in combating multiple complications of the medical catheter.