铑
催化作用
炔烃
共轭体系
胺气处理
化学
三键
级联反应
串联
原子经济
胺化
组合化学
有机化学
双键
材料科学
复合材料
聚合物
作者
Jie Chen,Jiahuai Han,Jian Zhang,Ling Li,Zhengyu Zhang,Yanhui Yang,Yaojia Jiang
标识
DOI:10.1021/acscatal.2c03777
摘要
Amines are powerful organocatalysts that are well-documented in catalyzing carbonyl compounds to realize transformations. However, they are rarely applied in alkyne activations. Herein, we disclose an efficient amine/Rh(II) dual catalytic system to reassemble the C≡C bond of conjugated alkynes with cyclopropenes, which enables construction of α-vinyldicarbonyl derivatives under very mild reaction conditions. Vinyl cyclopropylamines might be involved as key intermediates through ring-opening of cyclopropenes, catalytic amination of alkynes, and tandem cyclopropantion sequences in high atom and step-economies. This formal cutting/insertion cascade platform is compatible with a broad substrate scope including complex natural and unnatural molecules for late-stage functionalization.
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