“On-water” Photochemical Thiol-Ene Reaction of N-Enoxybenzotriazoles

We report herein a photochemical thiol-ene coupling using N-enoxybenzotriazoles, significantly accelerated under “on-water” conditions. This approach achieves efficient coupling within just five minutes via a remarkably rapid radical chain reaction, attributed to enhanced EDA formation and accelerated radical addition through hydrophobic effect. The robustness of this method under various perturbation conditions underscores its potential for broad applications.