Endothelial circadian rhythm genes as prognostic modulators of tumor progression and immune interactions: insights from pan-cancer single-cell RNA sequencing

Endothelial circadian rhythm genes play a significant role in regulating tumor progression, immune interactions, and patient prognosis. Dysregulation of the ENDO.CIRCADIAN.RHYTHM.SIG gene set correlates with adverse clinical outcomes and may serve as a potential prognostic biomarker and therapeutic target. Our findings suggest that targeting circadian rhythm pathways within the TME could enhance personalized cancer treatment strategies.