生物
先天免疫系统
免疫系统
获得性免疫系统
免疫
免疫学
促炎细胞因子
白细胞介素22
白细胞介素
细胞因子
抗菌肽
细胞生物学
炎症
抗菌剂
微生物学
作者
Yo Okamura,Tomoya Kono,Masahiro Sakai,Jun-ichi Hikima
标识
DOI:10.1016/j.fsi.2022.108496
摘要
Interleukin (IL)-17 is a proinflammatory cytokine and plays essential roles in adaptive and innate immune responses against bacterial and fungal infections. Especially in mammalian mucosal tissues, it is well known that innate immune responses via IL-17A and IL-17F, such as the production of antimicrobial peptides, are very important for microbiota control. In contrast, interesting insights into the functions of IL-17 have recently been reported in several teleost species, although little research has been conducted on teleost IL-17. In the present review, we focused on current insights on teleost IL-17 and speculated on the different or consensus parts of teleost IL-17 signaling compared to that of mammals. This review focuses on the role of teleost IL-17 in intestinal immunity. We expect that this review will encourage a further understanding of the roles and importance of IL-17 signaling in teleosts.
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