助记符
有氧运动
心理学
物理医学与康复
电子游戏
认知
海马结构
干预(咨询)
神经可塑性
认知训练
功能磁共振成像
康复
神经科学
物理疗法
认知心理学
医学
精神科
计算机科学
多媒体
作者
Xiaoyu Cui,Wenjun Gui,Jingwen Miao,Xiaomei Liu,Xinyi Zhu,Zhili Zheng,Wenjie Wan,Qi Shao,Jutta Kray,Yang Jiang,Juan Li
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2022-12-03
卷期号:78 (8): 1436-1444
被引量:1
标识
DOI:10.1093/gerona/glac232
摘要
Mnemonic discrimination is very vulnerable to aging. Previous studies have reported that aerobic exercise and enriched cognitive stimulation (e.g., video games) could improve mnemonic discrimination in older adults. The animal model suggested that combining the 2 training methods could result in a larger improvement. However, there is limited evidence on the potential superior efficacy of combined intervention with human participants. Moreover, the neural basis of this potential superior is poorly understood.We conducted a 16-week intervention trial with 98 community-dwelling older adults assigned to one of the four groups (combined training, aerobic cycling alone, video game alone, or passive control). Mnemonic discrimination was measured as the primary behavioral outcome, hippocampal volume, and functional connectivity of the default mode network (DMN) were measured as neural indicators.Participants receiving the combined intervention demonstrated the largest effect size of mnemonic discrimination improvement. Magnetic resonance image results indicated aerobic exercising increased left hippocampal volume, while video-game training counteracted the decline of DMN functional connectivity with aging. The synergy of hippocampal structural and functional plasticity observed in the combined training group explained why the largest intervention benefits were obtained by this group.Despite the nonrandomized design (i.e., likely self-selection bias), our results provide new evidence that combined intervention of exercise and cognitive training is more effective than single intervention for older adults. Parallel to animal studies, aerobic exercise and the video game with enriched cognitive stimulation could induce hippocampal plasticity through separate structural and functional pathways.ChiCTR1900022702.
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