牙周膜干细胞与炎症微环境相互作用的主要生物学机制概述

Periodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell behavior changes in response to changes in the microenvironment, which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells. It has been confirmed that periodontal ligament stem cells (PDLSCs) are vital in the development of periodontal disease. Moreover, PDLSCs are the most effective cell type to be used for periodontium regeneration. This review focuses on changes in PDLSCs, their basic biological behavior, osteogenic differentiation, and drug effects caused by the inflammatory microenvironment, to provide a better understanding of the influence of these factors on periodontal tissue homeostasis. In addition, we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment.牙周炎是一种复杂的慢性炎症性疾病，在此过程中病原体的入侵导致了炎症微环境的发生。细胞的生物学性质在炎症微环境的作用下发生改变，同时又可以通过分泌细胞因子对牙周组织的炎症微环境进行调节。研究证明，牙周膜干细胞在牙周疾病过程中至关重要。此外，牙周膜干细胞被证明是在牙周组织再生过程中最有效的干细胞类型。本综述关注在炎症微环境影响下，牙周膜干细胞生物学性质、成骨分化能力以及药物对细胞的影响等方面，有利于进一步理解上述因素对牙周组织稳态的影响。另外，我们还对牙周膜干细胞影响炎症微环境的相关机制进行了讨论。.